Survivor and Dihydromyricetin (DHM)
Studies suggest Dihydromyricetin (DHM) relieves alcohol (EtOH) toxicity and prevents intoxication by curtailing the absorption of alcohol in the gastrointestinal tract and promoting alcohol metabolisation in the liver – it has even been proposed as a ‘novel anti-intoxication medication’, which serves as evidence of its potential. Recently, there has been considerable academic interest in this flavonoid, as promising data on an entire swathe of benefits is emerging.
‘Dihydromyricetin (DHM) exhibits health-benefiting activities with minimum adverse effects. Dihydromyricetin (DHM) has been demonstrated to show antioxidative, anti-inflammatory, anticancer, antimicrobial, cell death-mediating, and lipid and glucose metabolism-regulatory activities.’
What is Dihydromyricetin (DHM)?
Originally known as Ampelopsin, Dihydromyricetin (DHM) is the major active compound in the extract of these plants. It was isolated from an extract of the fruit of Hovenia Dulcis by Hase et al. (1997). Later, it was also found in the fruit-stalk of the plant (Park et al., 2015).
Dihydromyricetin (or DHM for short) is assigned the CAS number 27200-12-0 by the Chemical Absctracts Service and has the chemical formula; (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
Dihydromyricetin (DHM) belongs to a group of chemicals present in many types of plants called flavonoids - the name Ampelopsin is in recognition of once such source of flavonoids - Ampelopsis grossedentata. Flavonoids are associated with many health benefits, such as anti-inflammation, anti-carcinogenesis, anti-hepatotoxicity, relieving constipation, inhibition of lipid accumulation and many more (Panche et al. 2016).